Vitalizes cells from the inside out

NMN

Nicotinamide mononucleotide

About NMN

NMN (nicotinamide mononucleotide) is
a substance naturally produced in the bodies of humans and living organisms,
and is instrumental in producing the vital energy our cells need for all human activity.
Moreover, it is believed to slow down the effects of aging.

The frontlines of aging and longevity research.

In a yearlong effectiveness trial, NMN was administered to mice, with the outcomes indicating that, compared to ordinary mice, it helped reduce the effects of weight gain in middle age, curb decreased energy metabolism from age, curb decreased bone density, and curb decreased ocular function, among other types of organ degradation.
In addition, it has been found to be beneficial against other ailments such as diabetes, Alzheimer's disease, heart failure, kidney failure, and more.
In other words, these findings demonstrated the clear anti-aging effects of NMN.

Ailments in which sirtuins are implicated

Ailments in which sirtuins are implicated

Cell Metab. 2018 Mar 6;27(3):529-547.

Sirtuin family functionality and diseases

Molecular name
Localization site
Function
Related diseases
SIRT 1
Nuclei, cytoplasm
Glucose metabolism, fat oxidation, circadian rhythms, inflammatory diseases
Diabetes, dementia, lifespan
SIRT 2
Nuclei, cytoplasm
Cell growth inhibition, DNA damage, inflammatory diseases
Cancer, inflammatory diseases, heart disease, lifespan
SIRT 3
Mitochondria
Energy (ATP) synthesis, citric acid circuit, electron transport chain, oxidative phosphorylation, amino acid metabolism, lipid metabolism, protein metabolism, reactive oxygen species (ROS), mitochondrial quality control
Heart disease, neurodegenerative disease, acute nephritis, cancer
SIRT 4
Mitochondria
Amino acid metabolism, lipid metabolism, citric acid circuit
Cancer, obesity
SIRT 5
Mitochondria
Lipid metabolism, glycolysis, free radicals, urea cycle
Cancer, heart disease
SIRT 6
Nuclei
Genome stability, telomere and centromere control, DNA repair, glucose metabolism, lipid metabolism
Cancer, inflammatory diseases, heart disease, lifespan
SIRT 7
Nuclei
Ribosome biosynthesis, cell stress response
Metabolic disease, cancer, lifespan

Introductory Review on Sirtuins in Biology, Aging, and Disease,1st Edition. 2018 Academic Press.

Curb the effects of aging by
consuming NMN on a daily basis

NMN is found in breast milk and vegetables with high beta-carotene, such as broccoli, avocadoes, and green soybeans. However, the quantity found in these foods is extremely minimal. NMN is converted into NAD in the body, but this gradually decreases with age. In our late 50s, its quantity is nearly half of what it once was, and continues to decline thereafter. As a result, it becomes impossible to supplement it with food alone. Therefore, consuming NMN like a supplement is a means of curbing the onset of aging.
NMN content image

NMN content in food

Food
NMN content
mg/kg-food
Food weight
(kg/250mg) *-NMN
How much should you consume to obtain 250mg* equivalent of NMN?
Reference
Edamame (green soybeans)
5 - 19
14 - 54
20,000 pieces
3g/bean Bean: pod = 1:1 weight
Broccoli
3 - 11
22 - 100
4,000 pieces
350g/bunch 25g/piece
Cucumber (seed)
6
44
-
140g /cucumber
Cucumber (skin)
7
38
-
140g /cucumber
Cabbage
0 - 9
0 - 28
28 pieces
1kg/piece
Avocado
4 - 16
16 - 70
600 avocados
170g/piece 120g (edible portion)/piece
Tomatoes
3
84 - 96
600 tomatoes
150g/piece
Mushrooms
0 - 10
0 - 24
2,000 mushrooms
12g/piece
Beef (raw)
1 - 4
60 - 416
2,000 steaks
150g/steak
Shrimp
2
114
10,000 shrimp
10g/piece

*Amount currently consumed by humans in clinical studies of NMN

Cell Metab. 2016 Dec 13;24(6):795-806.

NMN content in raw milk

Type
NMN content (μM) in milk
NMN content (mg/L-milk)
How much should you consume (in liters) to obtain 250mg* equivalent of NMN?
Reference
Human milk
6.1
2.0
122
-
Cow milk
0.9
0.3
832
(not contained in commercially available milk)
Buffalo milk
0.0
0.0
-
-
Sheep milk
0.3
0.1
2,494
-
Goat milk
2.1
2.1
356
-
Donkey milk
0.4
0.1
1,870
-

*Amount currently consumed by humans in clinical studies of NMN

Food Chem.2017 Apr 15;221:161-168

Mechanisms to suppressing aging and the role of NMN

Here we describe NAD, mitochondria, and sirtuin in order to help you better understand the mechanisms behind suppression of aging and the role played by NMN.
NMN content image

NMN

When consuming NMN through the mouth,
it passes through NMN transporters present on the cell surface and is absorbed into cells,
where it is converted into NAD.
↓

NAD

NAD (nicotinamide adenine dinucleotide) can be found in the cells of every living organism,
and is the source of the body's internal metabolism, being used whenever energy is produced.
However, NAD production begins to decrease in the body as we age.
Moreover, research has found that when consumed directly, NAD tends not to reach the cells,
so consuming NMN, a NAD precursor, is a more efficient means of delivering it to the body.
Attention is being drawn to NAD for its potential use in anti-aging using the two methods below.
↓

Synthesis of energy (ATP) in the mitochondria

ATP refers to a source of energy that all living things use to survive. All eukaryotic cells and most archaebacteria and bacteria use NAD to synthesize ATP. NAD is essential to the synthesis of ATP; without it, living organisms die.

Sirtuin (SIRT) activation

The mechanisms behind aging hinge on an enzyme called sirtuin. This may be an unfamiliar term, but it is a protein that exists widely in organisms from bacteria to mammals, and plays a special role in controlling aging and lifespan. Humans possess a class of seven proteins called sirtuins that help control aging of the organs, but these sirtuins are normally dormant. NAD functions as a switch that acts on all seven of these sirtuins. In other words, as NAD declines through aging, the "switch" controlling sirtuins stops functioning, which is believed to contribute to decreased organ and tissue function.

Through NAD upregulation, NMN activates sirtuins to help curb aging.

Through NAD upregulation, NMN activates sirtuins to help curb aging.
About NOMON
Our mission is to help people and society maintain a better standard of living,
both mentally and physically, for the long run.

We aim to enable people everywhere to
lead fulfilling lives true to themselves and pursue
the concept of "productive aging".

LIFE IS LONG.