The power of wasabi which protects cells from various external stressors
Wasabi sulphorafane™
6-MSITC
(6-Methylsulfinylhexyl isothiocyanate)

About wasabi sulphorafane™

Wasabi sulforaphane (6-Methylsulfinylhexyl isothiocyanate) is a nutrient
obtained by removing the pungent substances found in the rhizome of the wasabi plant,
and found in small quantities therein, which has excellent antioxidant properties
and aids in curbing the production of free radicals.

Efficacy of wasabi sulforaphane

This substance has been recognized for its ability to reduce oxidative stress, improve skin blemishes and freckles, and its anti-inflammatory properties in ameliorating knee joint pain. It has also been demonstrated to help suppress platelet aggregation and can improve circulation. (*1)

*1 Kinjirushi Wasabi Functionality Laboratory: Wasabi-sulfinyl® functionality
http://www.wasabi-labo.jp/sulfinyl/function/

Effects of wasabi sulforaphane on external stressors and brain neurons

わさびスルフォラファンの様々な外的ストレス、脳神経細胞に対する効果 図

*The image describes the possible effects of wasabi sulphorafane™ based on clinical and non-clinical data.
This is not intended as a claim of actual outcomes in humans from the use of wasabi sulphorafane™.

Free radicals are one cause of arteriosclerosis and lifestyle diseases, and cause the degradation of various cells and tissue. In the sense that it prevents the occurrence of these phenomena, wasabi sulforaphane can be thought of as a form of anti-aging support. Not only do wasabi sulphorafane™'s antioxidant properties contribute to its anti-aging benefits, but it has also been reported to curb cognitive impairment when used in Alzheimer's disease model mice. (*2)

※2 Molecular and Cellular Biology, 27 Feb 2020, 40(6)

About wasabi

Wasabi (scientific name: Wasabia japonica Matsumu.) is a Japanese plant in the Brassicaceae family that grows in streams deep in the mountains. This vegetable is considered good for the body, but it has a very strong and pungent taste, making it impossible to eat in large quantities. Food-grade wasabi sold in tubes and intended to be stored at room temperature contains many preservatives and additives, with the actual quantity of wasabi sulphorafane™ being quite minimal. Wasabi is a plant native to Japan and is believed to have been used as a source of nutrition during the Asuka period (550-710 CE). It is also used as a condiment with sushi and sashimi because of its disinfectant and antibacterial properties (*3).There are a number of ongoing tests today into the efficacy of wasabi for various uses.

*3 These effects do not take place within the human body.
わさび写真

About free radicals(reactive oxygens) and antioxidants.

Living organisms use about 20% of oxygen found in in the atmosphere. Oxygen reacts to external stimuli and changes into active oxygen in order to enable cell transmission and immune function.
However, excessive occurrence of this phenomenon can damage cells and cause various diseases such as cancer, cardiovascular disease, and lifestyle disease. While the body contains internal antioxidant functionality to protect cells from free radicals, antioxidants further assist in this process. The body's antioxidant ability gradually declines with age, and undergoes a rapid decline starting in the 40s.
体内の抗酸化力 グラフ

SOD:Superoxide dismutase Blood 1990 76 : 835-841

図

Antioxidant benefits of wasabi sulforaphane

Common antioxidants such as polyphenols work directly on free radicals to remove them. However, the antioxidant effect of wasabi sulforaphane found in the plant works in a completely different way, acting directly on cells to prevent them from producing free radicals in the first place. In other words, it enhances the cells' inherent antioxidant capabilities. In a test conducted on mice, the production of free radicals was curbed by 48%, and when wasabi sulphorafane™ was applied once to rat cells, it led to the increased expression (for over 24 hours) of a protein that protects the cells from oxidative stress.

Moreover, one substance that plays a critical role in the process of protecting cells is NRF2. NRF2 is activated by oxidative stress caused by free radicals, and acts by protecting cells. Recent findings have revealed that a lack of NRF2 impairs the body's ability to withstand environmental and other external stressors, as well as makes it more susceptible to internal stressors like free radicals. Moreover, experiments using mice have already demonstrated that Wasabi-sulfinyl®, which contains wasabi sulforaphane, effectively activates NRF2.

Cf. J Pharmacol Sci 115, 320-328(2011)
図

*The image describes the possible effects of wasabi sulphorafane™ based on clinical and non-clinical data.
This is not intended as a claim of actual outcomes in humans from the use of wasabi sulphorafane™.

About NOMON
Our mission is to help people and society maintain a better standard of living,
both mentally and physically, for the long run.

We aim to enable people everywhere to
lead fulfilling lives true to themselves and pursue
the concept of "productive aging".

LIFE IS LONG.